Have tried various Prostate supplements before without any noticeable effect. Then I checked on Web MD (I think !) and looked at the supplements that had medical evidence supporting their claimed action and those which did not. Made list and Doctors Best were the only product to contain proper amount of all substances shown to work ( also has some stuff that has little medical research support). Almost from start these have made a noticeable improvement in my symptoms of Benign Prostatic Hypertrophy. This supplement id definitely worth trying.